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World's No. 1* Lactic acid bacteria

LGG® is the world's No.1* probiotic lactic acid bacteria.
It is a live lactic acid bacteria that has a positive impact on human health by improving the balance of intestinal flora. Various studies are being conducted around the world.

*The number of research reports is the highest in the world, based on searches including “Lactobacillus rhamnosus GG” in PubMed (in-house research, search date: June 30, 2023)
*LGG® is a registered trademark of Chr. Hansen A/S.

EVIDENCE

The world's best-researched lactic acid bacteria.
The most researched probiotic.

LGG® has been selected by physicians and scientists around the world and is the most researched lactic acid bacteria in the world*.

There are more than 1,500 research reports, diverse scientific studies on human subjects, and more than 250 clinical studies have been reported.
This is about 40 times more data than the lactobacilli that everyone knows in Japan. It is a very unique lactic acid bacteria with huge research investment and new reports are discovered every day.

The health fields most studied are the digestive system, the immune system, and the oral system, and in these fields, health reports for infants, children, and adults have been approved.

Thus, this bacterium is regarded as a representative of the lactic acid bacteria world and is also called “utility lactic acid bacteria” because various studies have been conducted all over the world.

*The number of research reports is the highest in the world, based on searches including “Lactobacillus rhamnosus GG” in PubMed (in-house research, search date: June 30, 2023).
※LGG® is a registered trademark of Chr. Hansen A/S.

STRENGTHS

The power to stay in the intestines is about 8 times stronger.
The secret of its strength is the power of “Piri”.

For the intestinal environment, it is important that lactobacilli reach the intestines alive.

LGG® has superior acid resistance compared to other lactic acid bacteria, so it can reach the intestines alive without being defeated by stomach acid or bile acid.

And LGG® has special “pili” (linear hairs) that do not exist in common lactic acid bacteria. Thanks to the pili, LGG® can stay in the intestines for a long time, and its power is 8 times* that of other lactic acid bacteria. This allows them to continue working in the intestines for a long time, which has a positive effect on the intestinal flora.

*Rasinkangas et al.,Appl Enriron Microbiol 80(22):7001-9(2014)

SAFETY

Safe for pregnant women and infants.
30Safe to use for over 30 years.

Currently in Japan, there are almost no clinical trials of lactic acid bacteria as a food for pregnant women and infants.

However, LGG® has been studied and safety tests have been conducted on various health areas for newborns, children, pregnant women, adults, and the elderly, and there are no safety issues.

　　　　　　　

LGG® is a lactic acid bacteria isolated from the intestinal tract of a healthy human being* and is very safe for humans. Furthermore, it has been used worldwide as a dietary supplement since 1990, and there are no safety issues.

*Goldin BR, et al. Dig Dis Sci. 1992;37(1):121-8.

CERTIFICATION

European QPS certification.
Listed in the U.S. GRAS.

LGG® has obtained QPS (Qualified Presumption of Safety) certification in Europe*.

It is also listed as a GRAS (Generally Recognized as Safe) substance by the U.S. Food and Drug Administration*.

LGG® is controlled by Chr. Hansen Holding A/S, a leading supplier of probiotics worldwide, to ensure that it is always genomically identical*.

*EFSA Panel on Biological Hazards (BIOHAZ). EFSA Journal. 2015;13:4331.
*Food and Drug Administration. GRAS Notice Inventory > Agency Response Letter. GRAS Notice No GRN 000049. 2002.
*https://www.chr-hansen.com/en/human-health-and-probiotics/our-probiotic-strains/lgg